Figure 3 of
Klintworth, Mol Vis 4:31, 1998.
Figure 3. Families 2 and 3: Pedigrees and SSCP analyses of polymorphisms in exon 2 of the hLF gene used to investigate the relationship between the hLF genotype and FSCA in Families 2-11.
Family 2 (A): There are genotype differences between individuals that are affected with FSCA: 1 is homozygous for the Y polymorphism and 3, 4 and 7 are heterozygous with the X and Y polymorphisms. Since neither of the affected siblings parents (6 and 2) have FSCA linkage of hLF to FSCA disease can be ruled out in this family.
Family 3 (B): Affected individuals #3 and #5 do not carry the same hLF genotype as do affected individuals #6 and #7. Siblings #3 and #5 do not share the same SSCP hLF exon 2 profile as sibling #6. Since their parents are unaffected, hLF can be ruled out as candidate for the FSCA gene.