Figure 1. Pedigrees of five families screened for mutation in the TIGR/MYOC gene

Pedigrees include screened subjects and their first degree relatives. Generations consisting of individuals too young to determine the glaucoma phenotype are not shown. Males and females are indicated by squares and circles, respectively. Deceased members are indicated with a diagonal line through symbol. Individuals affected with glaucoma are indicated with filled symbols. Individuals whose glaucoma status or sex was indeterminate are indicated with a crosshatch inside the symbol or by diamonds, respectively. Individuals containing or lacking a co-segregating mutation identified in the proband are indicated by (+) or (-), respectively. Individuals in UM:GL7 and UM:GL57 containing or lacking a polymorphism are identified by (P) or (O), respectively.