Figure 2 of El-Kabbani, Mol Vis 1998; 4:19.

Figure 2. Schematic diagram of ARI structures

Spirohydantoins (e. g. sorbinil) and carboxylic acids (e. g. tolrestat and zopolrestat) represent two major classes of aldose reductase inhibitors. Our recent crystallographic studies have revealed that tolrestat and zopolrestat bind ALR1 and ALR2, respectively, at the active site.

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