Figure 1 of
El-Kabbani, Mol Vis 1998;
4:19.
Figure 1. The polyol pathway
Aldose reductase, the first and rate limiting enzyme of the polyol pathway, catalyzes the NADPH-dependent reduction of glucose to sorbitol. The pathway is completed by the second enzyme of the polyol pathway, sorbitol dehydrogenase, which converts sorbitol to fructose.