Figure 1 of El-Kabbani, Mol Vis 1998; 4:19.

Figure 1. The polyol pathway

Aldose reductase, the first and rate limiting enzyme of the polyol pathway, catalyzes the NADPH-dependent reduction of glucose to sorbitol. The pathway is completed by the second enzyme of the polyol pathway, sorbitol dehydrogenase, which converts sorbitol to fructose.

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