Figure 4. Clinical features across four genes. A: Clinical features of genes responsible for cornea plana, megalocornea and brittle cornea syndrome; In the percentage pie chart, the gray section represents the proportion of families carrying pathogenic variants in KERA, CHRDL1, ZNF469 and PRDM5 that do not exhibit the phenotype, relative to all families carrying pathogenic variants in KERA, CHRDL1, ZNF469 and PRDM5. The image was created by Biorender and Adobe illustrator. B: Age of exam and age of corneal rupture of KERA, CHRDL1, ZNF469 and PRDM5; (C) Race and sex of KERA, CHRDL1, ZNF469 and PRDM5.