Figure 1. Identification of differentially expressed genes (DEGs). A: Differential expression gene analysis was performed on the retinopathy of prematurity (ROP) dataset GSE135844. Blue nodes represented genes downregulated in ROP, red nodes represented upregulated genes, and gray nodes indicated genes with no significant difference compared with controls. B: The heatmap illustrated the expression patterns of the identified DEGs. The oxygen-induced retinopathy (OIR) model was commonly used to simulate the pathological process of ROP in experimental animals.