Figure 5. Effect of cassia polysaccharide-regulated PAX6-shRNA on scleral remodeling. A–C: The mRNA expression levels of COL1A1, MMP-2, and TGF-β in the cassia polysaccharide group were significantly increased compared with those in the PAX6 knockdown group, with no significant difference relative to the normal group. D–G: The protein expression levels of COL1A1, MMP-2, and TGF-β in the cassia polysaccharide group were also significantly increased compared with those in the PAX6 knockdown group, which was consistent with the mRNA expression trend (n=3; *p<0.05, **p<0.01, ***p<0.001, respectively).