Figure 4. CysLTR1 inhibition affects intracellular glucose levels in ARPE-19 cells. Relative and normalized intracellular glucose levels in ARPE-19 cells treated for 1 day or 3 days with 100 nM MK, 1,000 nM MK, 100 nM ZK, or 1,000 nM ZK under (A) standard and (B) high-glucose conditions. The data are presented as bar graphs ± SDs, n = 4-5. Repeated-measures two-way analysis of variance (main factors: treatment and time), followed by a Dunnett multiple comparison test, was performed. ##p < 0.001 and #p < 0.05 for the control group versus the treatment group. $$p < 0.001 and $p < 0.05 for the single control group versus the single treatment group. RLU, relative luminescence unit.