Figure 3. A comparison of CNGA3, CNGB3, and CNGA1 gene conservation among different homologs for novel variants identified in this study. A, C, E. Clustal Omega multiple sequence alignment (highlighted in red) for p.(Gly267Val), p.(Trp385Arg), and p.(Ile545Phe) detected in RD004, RD021, and RD053, respectively, showing high sequence conservation in diverse species. B, D, F. WebLogo3 results of three novel variants showing comparison of conservation among homologs. All identified variants show 100% conservation among different species (large size of amino acid abbreviation letters shows full conservation while small size shows less conserved position among homologs).