Table 2 of
Betts, Mol Vis 2024; 30:74-91. Table 2 of
Betts, Mol Vis 2024; 30:74-91.
Table 2. Tissue inhibitor of metalloproteinases 3 (TIMP-3) variants and their inhibitory ability.
| Mutation | Matrix metalloproteinases (MMP) inhibition (relative to wild-type TIMP-3) |
|---|---|
| Leu10His Gly12Arg | Not known. |
| Cys24Arg | Not known. |
| Ser38Cys | Not known. |
| Intron 4/Exon 5 Splice Site | Not known. |
| Ser149Cys | Not known. |
| Tyr151Cys | Not known. |
| Glu162Lys | Retains inhibition of MMP-2/9 [80]. |
| Glu162STOP | Retains inhibition of MMP-2/9 [68], with MMP-2 inhibition demonstrate for monomer [74]. |
| Reduced MT1-MMP inhibition [70]. | |
| Tyr174Cys | Not known. |
| Tyr177Cys | Not known. |
| Ser179Cys | Retains (monomer) inhibition of MMP-2/9 [83] [70]. |
| 2–3-fold lower Kon values for MMP-2/3/9/13 [77]. Reduced MMP-2/9 inhibition [81,82], increased MMP-9 activity in spleen tissue isolated from Ser179Cys+/+ mice [82], reduced inhibition of MT1-MMP [69,70]. | |
| Increased secretion and activation of pro-MMP-2/9 [69]. | |
| His181Arg | Proposed molecular modeling suggests that His181Arg have altered pro-MMP-2 activation [97]. |
| Tyr182Cys | Not known. |
| Gly189Cys | Retains inhibition of ‘MMPs’ in transfected COS-7 cells [75]. |
| Gly190Cys | Retains inhibition of MMP-2/9 [77]. |
| Tyr191Cys | Retained [77] or reduced inhibition of MMP-2/9 [81]. |
| Ser193Cys | Not known. |
| Tyr195Cys | Not known. |
| Trp198Cys | Not known. |
| Ser204Cys | Retains inhibition of ‘MMPs’ [73], MMP-2/9 [33,70,74,77] and MT1-MMP [70]. |
| Reduced inhibition of MMP-2/9 [81]. Due to increased accumulation, overall inhibition of MMP-2/9 was unaltered [72]. |