Figure 1. Clinical features of the proband. A, B: Physical examination showed a protuberant umbilicus. C: Dental examination revealed a missing upper incisor as well as some abnormally shaped teeth. D, E: Slit-lamp images revealed polycoria, corneal degeneration, and iris hypoplasia in both eyes. F, G: UBM revealed high insertion of the iris root and anterior synechia. H, I: Scanning laser ophthalmoscopey (SLO) indicated that the cup-to-disk ratio was 1.0 in both eyes.