Figure 8. Effects of Smad3 gene deficiency in TGFβ/Smad signaling in mice after alkali injury. A: TGFβ1 (p<0.001); B: Smad2 (p<0.01); C: Smad4 (p<0.05); and D: Smad7 comparative mRNA expression significantly altered in post-alkali injury tissue at day 21 in both Smad3^+/+ and Smad3^−/− strains as compared with corresponding naïve control mouse corneal tissue. Results are expressed as mean ± SEM, and p<0.05 was considered significant. (*p<0.05, ***p<0.01, and ns = not significant).