Figure 4. Smad3 gene deficiency tailored the inflammatory protein expression and impacted the corneal wound healing in mice after alkali injury. Expression of inflammatory protein CD11b expression in A: Smad3^+/+ naïve mouse corneal tissue; B: Smad3^−/− naïve mouse corneal tissue; C: Smad3^+/+ alkali-injured mouse corneal tissue at day 21; and D: Smad3^−/− alkali-injured mouse corneal tissue at day 21. The alkali injury increases the CD11b protein expression (arrow) in both strains of Smad3^+/+ and Smad3^−/− mouse corneal tissue as compared with naïve control mouse corneal tissue, respectively. Scale bar = 200 µm.