Molecular Vision: Altankhuyag, Mol Vis 2024; 30:320-335. Table 6

Table 6. Possible additive interaction of the risk factors with ARMS-2, CFH and VEGF-A genes polymorphisms in AMD.

Risk factors			Case (n=161)	Control (n=223)	cOR	95%CI	P value	RERI	AP	S
Risk factor		Genotypes	Case (n=161)	Control (n=223)	cOR	95%CI	P value	RERI	AP	S
Wear sunglasses	No	rs10490924 Non G/G	130	111	11.13	2.54-48.82	0.0014	6.086	0.547	2.506
		rs1061170 Non T/T	59	45	6.26	2.77-14.17	<0.001	1.445	0.231	1.378
		rs1065489 G/G	53	25	13.43	5.75-31.37	<0.001	-3.984	-0.297	0.757
		rs800292 G/G	20	2	37.5	7.92-177.51	<0.001	28.117	0.750	4.354
		rs833061 C/C	12	6	7.06	2.31-21.59	0.0006	1.566	0.222	1.348
		rs2146323 Non A/A	129	133	7.76	0.96-62.92	0.055	2.331	0.300	1.526
Hypertension	Yes	rs10490924 Non G/G	108	85	13.98	3.19-61.10	0.0005	5.850	0.419	1.821
		rs1061170 Non T/T	53	42	3.48	1.89-6.42	0.001	0.449	0.129	1.221
		rs1065489 G/G	47	16	9.05	4.38-18.68	<0.001	4.546	0.502	2.298
		rs800292 G/G	17	3	14.57	4.02-52.83	<0.001	-14.528	-0.997	0.483
		rs833061 C/C	10	4	5.88	1.73-19.95	0.0045	2.504	0.426	2.054
		rs2146323 Non A/A	111	110	2.83	0.98-8.11	0.054	1.319	0.467	3.601
Anti-coagulant	Yes	rs10490924 Non G/G	51	42	9.11	3.92-21.16	<0.001	-1.562	-0.171	0.838
		rs1061170 Non T/T	24	14	3.54	1.71-7.35	0.0007	0.838	0.236	1.491
		rs1065489 G/G	19	7	6.74	2.69-16.86	<0.001	0.734	0.109	1.147
		rs800292 G/G	9	0	35.38	2.04-614.83	0.014	26.528	0.750	4.380
		rs833061 C/C	5	2	4.37	0.83-22.95	0.082	0.720	0.165	1.272
		rs2146323 Non A/A	53	43	3.45	1.51-7.89	0.0033	1.075	0.311	1.781

Note: The values were given as number. P value by two-tailed Chi square (x2) test for 2x4 contingency table. Odds ratio and confidence interval was calculated by logistic regression. p<.005 indicated a statistically significant difference after Bonferroni correction (shown in bold). Abbreviations: cOR, Crude odds ratio; CI, Confidence interval; RERI, Relative excess risk due to interaction; S, Synergy index; AP, Proportion attributable.