Molecular Vision: Altankhuyag, Mol Vis 2024; 30:320-335. Table 5

Table 5. Best models of SNP-SNP interactions among all SNPs and AMD risk.

SNP x SNP interaction models	Bal.Acc.	Test.Acc.	CVC	cOR (95% CI)	X²	p value
rs10490924	0.638	0.589	5/10	3.10 (2.02-4.77)	27.47	<.001
rs10490924 x rs1065489	0.682	0.635	7/10	4.52 (2.93-6.99)	48.69	<.001
rs10490924 x rs1065489 x rs800292	0.714	0.643	7/10	6.07 (3.88-9.49)	67.29	<.001
rs10490924 x rs1065489 x rs1413711 x rs2010963	0.753	0.621	6/10	9.08 (5.64-14.62)	92.51	<.001
rs10490924 x rs1065489 x rs800292 x rs1413711 x rs2010963	0.794	0.641	4/10	14.78 (8.79-24.84)	123.99	<.001
rs10490924 x rs1065489 x rs800292 x rs2010963 x rs144854329 x rs2146323	0.834	0.651	6/10	29.03 (15.75-53.50)	161.24	<.001
rs10490924 x rs1065489 x rs800292 x rs1413711 x rs2010963 x rs2146323 x rs1570360	0.865	0.598	6/10	68.85 (30.41-155.87)	192.19	<.001
rs10490924 x rs1061170 x rs1065489 x rs800292 x rs1413711 x rs2010963 x rs2146323 x rs1570360	0.889	0.612	6/10	68.55 (33.81-138.96)	219.45	<.001
rs10490924 x rs1061170 x rs1065489 x rs800292 x rs1413711 x rs2010963 x rs144854329 x rs2146323 x rs1570360	0.901	0.625	10/10	93.88 (43.68-201.78)	234.6	<.001
rs10490924 x rs1061170 x rs1065489 x rs800292 x rs833061 x rs1413711 x rs2010963 x rs144854329 x rs2146323 x rs1570360	0.904	0.631	10/10	106.31 (47.81-236.39)	238.23	<.001

Note: The best model speculated by MDR is composed of rs10490924, rs1061170, rs1065489, rs800292, rs833061, rs1413711, rs2010963, rs144854329, rs2146323 and rs1570360. p<.005 indicated a statistically significant difference after Bonferroni correction. Abbreviations: Bal.Acc, Balanced accuracy; Test.Acc, Testing accuracy; CVC, Cross validation consistency; cOR, Crude odds ratio; CI, Confidence interval; X2, Chi-square.