Molecular Vision: Altankhuyag, Mol Vis 2024; 30:320-335. Table 4

Table 4. Comparison of genotype frequencies of SNPs in genetic models between the groups.

Gene	refSNP ID	Genetic model	Risk genotypes	cOR	95%CI	P value	Power	aOR	95%CI	P value	Power
ARMS2	rs10490924 T allele	Do*	T/T+T/G	4.45	2.44-8.13	<0.001	100%	5.08	2.70-9.59	<0.001	99.5%
		Re	T/T	3.01	2.02-4.77	<0.001	100%	3.41	2.14-5.43	<0.001	99.3%
		In Do	T/G	0.84	0.56-1.28	0.421	12.4%	0.86	0.56-1.33	0.496	2.2%
CFH	rs1061170 C allele	Do	C/C+T/C	1.86	1.21-2.85	0.004	80.8%	1.97	1.25-3.10	0.003	51.1%
		Re*	C/C	4.02	1.25-12.85	0.019	71.1%	4.59	1.36-15.53	0.014	41.3%
		In Do	T/C	1.52	0.98-2.36	0.06	46.6%	1.58	0.99-2.51	0.054	17.7%
CFH	rs1065489 G allele	Do	G/G+G/T	0.86	0.45-1.64	0.645	6.9%	1.00	0.51-1.98	0.993	1.0%
		Re*	G/G	4.19	2.53-6.93	<0.001	100%	4.67	2.71-8.05	<0.001	99.8%
		In Do	G/T	0.30	0.19-0.46	<0.001	100%	0.29	0.18-0.47	<0.001	99.7%
CFH	rs800292 G allele	Do	G/G+A/G	2.17	1.34-3.50	0.002	90.2%	2.09	1.26-3.47	0.004	65.8%
		Re*	G/G	11.61	3.41-39.51	<0.001	99.5%	12.49	3.47-44.91	<0.001	96.7%
		In Do	A/G	1.12	0.73-1.72	0.609	7.3%	1.06	0.67-1.67	0.807	1.1%
VEGF-A	rs833061 C allele	Do	T/C+C/C	0.97	0.65-1.46	0.901	57.1%	0.91	0.59-1.40	0.678	26.8%
		Re*	C/C	2.71	1.06-6.96	0.038	56.9%	2.81	1.04-7.55	0.041	26.7%
		In Do	T/C	0.79	0.53-1.20	0.279	18.9%	0.75	0.48-1.16	0.192	4.2%
VEGF-A	rs1413711 C allele	Do	C/C+C/T	1.29	0.62-2.71	0.499	9.6%	1.58	0.72-3.50	0.255	1.5%
		Re*	C/C	1.13	0.75-1.70	0.556	8.6%	1.23	0.80-1.91	0.331	1.3%
		In Do	C/T	0.96	0.64-1.44	0.839	3.9%	0.93	0.61-1.43	0.744	0.5%
VEGF-A	rs2010963 G allele	Do	G/G+C/G	1.26	0.83-1.91	0.271	19.4%	1.32	0.85-2.04	0.215	4.3%
		Re*	G/G	1.44	0.75-2.77	0.276	19.9%	1.45	0.72-2.94	0.300	4.7%
		In Do	C/G	1.09	0.73-1.64	0.677	6.2%	1.14	0.74-1.74	0.554	0.8%
VEGF-A	rs144854329 Del allele	Do*	Del/Del+Del/Ins	1.31	0.64-2.67	0.458	10.8%	1.45	0.69-3.07	0.329	1.8%
		Re	Del/Del	1.02	0.68-1.53	0.928	3.1%	1.06	0.69-1.63	0.774	0.3%
		In Do	Del/Ins	1.07	0.71-1.62	0.728	5.3%	1.07	0.69-1.64	0.773	0.7%
VEGF-A	rs2146323 C allele	Do*	C/C+C/A	1.94	1.02-3.66	0.042	54.0%	2.15	1.10-4.22	0.025	21.6%
		Re	C/C	0.98	0.65-1.47	0.918	3.2%	1.01	0.66-1.54	0.971	0.3%
		In Do	C/A	1.39	0.92-2.13	0.117	34.8%	1.43	0.91-2.23	0.117	10.9%
VEGF-A	rs1570360 G allele	Do	G/G+G/A	1.25	0.48-3.25	0.646	6.4%	1.27	0.47-3.45	0.636	0.8%
		Re*	G/G	1.38	0.89-2.13	0.142	31.0%	1.62	1.02-2.57	0.040	8.8%
		In Do	G/A	0.74	0.47-1.16	0.190	25.6%	0.62	0.39-1.01	0.055	6.5%

Note: The values were given as number (proportion). P value by two-tailed Chi square (x2) test for 2x4 contingency table. Odds ratio and confidence interval was calculated by logistic regression. Adjusted for the variables that age, gender, BMI, education level, occupational exposure of dust, smoking status, living residence, hypertension, use of anticoagulant or antiplatelet medication and wear sunglasses. p<.005 indicated a statistically significant difference after Bonferroni correction (shown in bold). *Suggested genetic model by four-model strategy calculation. Abbreviations: Do, Dominant; Re, Recessive; In Do, Incomplete dominant; cOR, Crude odds ratio; aOR, Adjusted odds ratio; CI, Confidence interval.