Table 1 of
Phillips, Mol Vis 2024; 30:239-259. Table 1 of
Phillips, Mol Vis 2024; 30:239-259.
Table 1.
| Various | GK rat (Type II) | HFD+STZ rat (Type II) | HFD+STZ rat (Type I) | STZ rat (Type I) |
|---|---|---|---|---|
| Hyperglycemia | moderate | moderate | high | high |
| Source of hyperglycemia | polygenic | diet + low dose STZ | diet + low dose STZ | high dose STZ |
| Insulin dependent? | No | No | Occasionally | Often |
| ERG changes at | 4 weeks | 8 weeks | 8 weeks | 4–8 weeks |
| ERG amplitude | greatly increased | same as control | slightly decreased | same or slightly decreased |
| ERG implicit time | delayed | delayed | trend for delay | delayed |
| Optomotor response changes at | NA (albino) | 2–4 weeks | 2–4 weeks | 2–4 weeks |
| Cognitive deficits at | 6 months | —- | —- | 8 weeks |
| Exploratory deficits at | 8 weeks | —- | —- | 8 weeks |
| Vascular function deficits | not observed by 8 months | —- | —- | 2 weeks |
| Vascular pathology | not observed by 1 year | —- | —- | 6–8 months (varies by strain) |
| Retinal dopamine | Increased | Not reduced (at 10 wks) | Reduced | Reduced |