Figure 5. Type II rats showed deficits in both spatial frequency and contrast sensitivity. A: Spatial frequency and (B) contrast sensitivity assessed through optomotor response at baseline, pre-STZ, 2-, 4-, 6- and 8-weeks post-hyperglycemia. The colored asterisks correspond to a significant difference with the group that shares the color of the asterisks. Black asterisks correspond to a significant difference with every other group. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001. Results expressed as mean ± SEM.