Figure 4 of Fuma, Mol Vis 2024; 30:219-228.


Figure 4. Role of Atf4 in an RVO murine model. (A) Immunohistochemistry of ATF4 (green) and Hoechst 33,342 (blue) 24 h after occlusion. GCL; ganglion cell layer, INL; inner nuclear layer, ONL; outer nuclear layer (B) Quantitative data of INL thickness of the occluded retinas after IV injection of ISRIB. Results are the mean ± SEM (n = 5–12). *p<0.05, **p<0.01 versus vehicle, #p<0.05, ##p<0.01 versus control (Tukey’s test). (C) Expressions of Vegf, Tnf-α, and Il6 in occluded retinas 12 h after ISRIB injection. Results are the mean ± SEM (n = 5–12). *p<0.05, **p<0.01 versus vehicle, #p<0.05, #xss#p<0.01 versus control (Tukey’s test).