Figure 3. Pathway analysis. A: KEGG pathway analysis of regulated proteins performed in GeneCodis 4.0. Significantly regulated proteins were involved in complement and coagulation cascades, glycolysis/ gluconeogenesis, cholesterol metabolism, ECM-receptor interaction, and the HIF-1 signaling pathway. B: A large group of proteins were involved in complement and coagulation cascades, including complement factors (C2, C3, C4B, C5, C6, C7, C8A, C8G, C9, and CFH), fibrinogen chains (FGA, FGB, and FGG), vitronectin (VTN), alpha-1-antitrypsin (SERPINA1), antithrombin-III (SERPINC1), heparin cofactor 2 (SERPIND1), alpha-2-antiplasmin (SERPINF1), plasma kallikrein (KLKB1), kininogen-1 (KNG1), alpha-2-macroglobulin (A2M), and prothrombin (F2).