Figure 1 of Shearer, Mol Vis 3:8, 1997.

Figure 1. Mechanism of selenite nuclear cataract formation

Altered epithelial metabolism
(oxidation, DNA and RNA metabolism, calcium homeostasis)

Calcium accumulation in nucleus

Activation of m-calpain (calpain II)

Proteolysis and loss of N-terminal extensions on ß-crystallins

Insolubilization of proteolyzed ß- and alpha-crystallins,
co-precipitation of gamma-crystallins

Light scatter and cataract
Selenite nuclear cataract (5K)

Shearer, Mol Vis 1997; 3:8 <>
©1997 Molecular Vision
ISSN 1090-0535