Figure 8 of
Mol Vis 3:3, 1997.
Figure 8. Proposed mechanism of Na,K-ATPase inhibition by 12 (R) HETE
Twelve (R) HETE forms a dimer with Ca+2 at the plasma membrane outer surface and transports calcium intracellularly. Upon dissociation of the dimer, Ca+2 competes with Na+ for the sodium binding site (or its adjacent area) preventing Na+ binding and, thereby, inhibits the enzyme.