Figure 5. The induced myopia expression of some GO/GROW signature genes is OPN3 dependent. A: Chart quantifying changes in the expression of a selection of GO/GROW signature genes in response to a −30-diopter lens in control Opn3^+/+ (gray bars) and experimental Opn3^Ex2/Ex2 (blue bars) mice. Gene expression is shown as log₂ fold change; negative values mean decreased expression, and positive values mean increased expression. B: Schematic explaining the changes in eye shape that occur in the Opn3 germline null mice. These include reduced aqueous depth and reduced lens thickness. n=4 for all biologic replicates.