**Figure 4. **The susceptibility of *Opn3* null mice to LIM is largely unchanged. Relative change in ocular biometry in mice of the *Opn3*^{Ex2/Ex2} (top row) and *Opn3*^{fl/fl}; mRx-cre genotypes (bottom row) in the LIM model. The data show the change in axial length (**A**, **D**) and refraction (**C**, **F**) when comparing a left eye treated with a 0 diopter lens and a right eye treated with a −30 diopter lens. For choroidal thickness
(**C**, **F**), the charts show only the 3-week (t=0) time point compared with the 6-week time point for the right eye, −30 diopter lens.
Although the *Opn3*^{Ex2/Ex2} mice showed an apparent reduced susceptibility to choroidal thinning (B, blue and black dashed traces) and refractive shift
(**D**, compare blue and black dashed traces), these changes did not reach statistical significance (goggled *Opn3*^{Ex2/Ex2} n=8, goggled control n=8; ungoggled *Opn3*^{Ex2/Ex2} n=5, ungoggled control n=4; goggled *Opn3*^{fl/fl}; mRx-cre n=10, goggled control n=7; ungoggled *Opn3*^{fl/fl}; mRx-cre n=10; ungoggled control n=11).