Figure 4. The susceptibility of Opn3 null mice to LIM is largely unchanged. Relative change in ocular biometry in mice of the Opn3^Ex2/Ex2 (top row) and Opn3^fl/fl; mRx-cre genotypes (bottom row) in the LIM model. The data show the change in axial length (A, D) and refraction (C, F) when comparing a left eye treated with a 0 diopter lens and a right eye treated with a −30 diopter lens. For choroidal thickness (C, F), the charts show only the 3-week (t=0) time point compared with the 6-week time point for the right eye, −30 diopter lens. Although the Opn3^Ex2/Ex2 mice showed an apparent reduced susceptibility to choroidal thinning (B, blue and black dashed traces) and refractive shift (D, compare blue and black dashed traces), these changes did not reach statistical significance (goggled Opn3^Ex2/Ex2 n=8, goggled control n=8; ungoggled Opn3^Ex2/Ex2 n=5, ungoggled control n=4; goggled Opn3^fl/fl; mRx-cre n=10, goggled control n=7; ungoggled Opn3^fl/fl; mRx-cre n=10; ungoggled control n=11).