Figure 9. Eye drop instillation of SOCS3-KIR enhanced antioxidant enzymes in the retinas of mice treated with sodium iodate. Mice (n = 4 in each group) were treated on day −1 until day 3 with R9-SOCS3-KIR or the control peptide (15 μg in 2 μl in each eye) and injected i.p. on day 0 with sodium iodate. On day 3, the retina was isolated and used for RNA extraction and qRT-PCR with the target antioxidant enzymes and then compared with β-actin, which served as the internal control. In each comparison, the Student’s t-test for unpaired data was used to establish statistical significance for each comparison. **, p < 0.01; ***, p < 0.001. Abbreviations: HO-1, heme oxygenase 1; GSTM1, glutathione S-transferase Mu 1; NQO-1, NAD(P)H quinone dehydrogenase 1.