To access the data, click or select the words “Appendix 1.” A: Mouse macrophage cells, J774.1 were pre-treated with indicated concentrations of R9-SOCS3-KIR or the control peptide (20 μM) for 1 h, followed by addition of LPS (1 μg/ml) and the treatment overnight. Supernatants were harvested and used for NO estimation using Griess reagent. (B). J774A.1 cells were pre-treated with R9-SOCS3-KIR or its control peptide (20 μM) for 1 h, followed by addition of LPS (1 μg/ml) and treatment overnight. Supernatants were harvested and used for quantitation of IL-1β by ELISA. One-way ANOVA (ANOVA) followed by Tukey’s test for multiple comparisons showed significant differences. **, p<0.01; ***, p<0.001; ****, p<0.0001. (C) J774A.1 treated as described were lysed to obtain cell extracts. Equal amounts of proteins were separated on a polyacrylamide gel, transferred to PVDF membrane and probed with antibodies to COX-2 and α-tubulin as an internal control. (D) The experiment as above was repeated three times for quantitation. The relative intensities of COX-2 and α-tubulin from three different blots were measured using image J software and averaged. One-way ANOVA followed by Tukey’s test for multiple comparisons showed significant differences between the treatments. **, p<0.01; ****, p<0.0001.