Figure 3. Evolutionary conservation of variant nucleotides identified by genetic testing. (A) Family tree for subject P1. The homozygous mutation affecting codon Arg478 is conserved in mouse (Mou), chicken (Chk), and zebrafish (Zeb) TTLL5 proteins. (B) Family tree for subject P2. The heterozygous mutation affecting codon Leu81 and the heterozygous mutation codon Ala795 are also conserved through evolution.