Figure 3. ZK002 reduced proangiogenic factors expression in SD rats after corneal alkali burn. RT qPCR was used to detect the mRNA levels of proangiogenic factors VEGFR2 (A), MMP-9 (B), and MMP-2 (C) in alkali-burned corneas. Data were expressed as the mean ± SD. Data were analyzed using analysis of variance and Dunnett’s multiple comparison test. Compared all groups vs. Each group. A value of p < 0.05 was considered statistically significant. *p < 0.05, **p < 0.01, ***p < 0.0001. Representative immunohistochemistry of MMP-9 (D) and VEGFR2 (E) on day 14 in corneal sections are shown. Bar = 100 µm.