To access the data, click or select the words “Appendix 2.” Comparison of the Alphafold2 (AF2) generated WT full-length and domain-specific ABCA4 models with the experimental structures. A. AF2-predicted full-length (FL) ABCA4 protein model colored based on the pLDDT score. B. Superimposition of AF2 domain-specific models ECD1 (green), TMD1 (yellow), NBD1 (cyan), R1 (purple), ECD2 (magenta), TMD2 (blue), NBD2 (salmon), R2 (pink) on human ABCA4 cryo-EM structures (gray), demonstrating the high structural similarity between AF2-predicted models and the available cryo-EM structures of human ABCA4 protein. Visualized in PyMol2.