Table 2 of
Nagaraj, Mol Vis 2023; 29:125-139. Table 2 of
Nagaraj, Mol Vis 2023; 29:125-139.
Table 2. List of pathways deregulated upon LOX-PP overexpression in Y79 retinoblastoma cells.
| Pathway name | Upregulated genes | Downregulated genes | p value |
|---|---|---|---|
| Retinoblastoma (RB) in Cancer | MDM2,CDKN1A,MIR29B1 | HDAC1,SKP2,TP53,PLK4,CCNB1CCNB2,MCM6,RFC5, POLA1,PRIM1,ORC1,CHEK1,TTK,SMC2,KIF4A,HMGB1, SMC1A,FAF1,POLD3,RBBP4,E2F3 | 0 |
| Cell Cycle | MDM2 | ATR,BUB1,BUB3,HDAC1,HDAC8,CCNB1,CCNB2,SKP2,SMC1A,E2F3,E2F5,CDC20,APC,YWHAG,YWHAB,MCM6,MCM8,ORC1,ORC2,ORC6 | 0.000032 |
| Notch Signaling Pathway | CDKN1A,HES1 | MAML2,APH1A,NCSTN,MAML3,HDAC1,NUMB,JAK2 | 0.048418 |
| Focal Adhesion-PI3K-Akt-mTOR-signaling pathway | ITGB5,IL2,MDM2,CDKN1A | JAK2,IGF1R,KRAS,RAB10 | 0.000412 |
| Apoptosis Modulation and Signaling | MIR29B1,CASP4 | CASP2,TRAF6,TP53,MCL1 | 0.023205 |
| DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM | MDM2 | ATR,EXO1,MRE11A,ACTL6A,TP53,DCLRE1C,TRAF6,BLM,BRCA2, SMC1A,LATS1,BRCA1,RNF8,RIF1 | 0.000021 |
| DNA IR-damage and cellular response via ATR | MDM2 | ATR,FANCI,MRE11A,TP53,SMC1A,BLM,XRCC5,BRCA2,EXO1,EEF1E1, TDP1,BRCA1,RNF8,TOPBP1,BRIP1,HUS1,WRN,FOXM1 | 0.000147 |
| DNA Damage Response | GADD45A,CDKN1A,DDB2,MDM2 | ATR,SMC1A,CCNB1,CHEK1,TP53,BRCA1,HUS1,CCNB2 | 0.004928 |
| Nucleotide Excision Repair | CHD1L,TCEA1,RNF111 | 0.002604 | |
| Signaling by FGFR2 | BRAF | 0.000011 |