Table 2 of Sangwan, Mol Vis 2022; 28:526-535.

Table 2. Genotype frequencies of interleukins in SJS/TEN patients and controls.

Gene Genotype
Patient (%) Control (%)
Patient n=100 n=131 p-value Minor Allele Frequency (MAF)
Present study All American East Asian European South Asian
IL-4 promoter (rs2243250) CC 65 (65) 77 (58.8)
CT 23 (23) 52 (39.7)
TT 12 (12) 2 (1.5) 0.59 0.21 0.47 0.37 0.22 0.17 0.18
IL-4R coding (rs1801275) AA 70 (70) 66 (50.4)
AG 25 (25) 61 (46.6)
GG 5 (5) 4 (3.1) 0.02* 0.26 0.38 0.32 0.17 0.21 0.24
IL-13 promoter (rs1800925) CC 69 (69) 87 (66.4)
CT 29 (29) 38 (29.0)
TT 2 (2) 6 (4.6) 0.47 0.19 0.25 0.23 0.18 0.18 0.20
IL-13 coding (rs20541) GG 58 (58) 83 (63.4)
GA 34 (34) 41 (31.3)
AA 8 (8) 7 (5.3) 0.31 0.21 0.27 0.38 0.36 0.21 0.27

Screening for polymorphisms of interleukins showed C/T change for IL-4 promoter region, A/G change for IL-4R coding region, C/T change for IL-13 promoter region and G/A polymorphism for IL-13 coding region. Minor allele frequency is shown for different populations. *p<0.05.

Sangwan, Mol Vis 2022; 28:526-535. http://www.molvis.org/molvis/v28/526

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