Figure 1. Chronic unpredictable mild stress (CUMS) mice presented depression-like behaviors and reduced weight gain. A: Bodyweight was measured weekly for both groups. CUMS mice gained weight more slowly than control mice did. The mice exposed to CUMS were significantly lighter than the normal controls as of week 3 (n = 9–12). B: The blood of the mice was collected and measured at the end of 5 weeks of exposure. The serum corticosterone level was higher in the CUMS mice than in the normal group (n = 5–5), which indicated a higher stress level of CUMS mice. C: The immobility time was examined in the forced swim test (FST). D: Sucrose consumption was determined using the sucrose consumption test (SCT) at the end of 5 weeks of CUMS exposure. Our results showed increased immobility time in the FST and decreased sucrose consumption in the SCT. Data are presented as mean ± standard error of the mean (SEM), n = 9–12. *p<0.05, **p<0.01, ***p<0.001.