Figure 3. LXA4 treatment activates Nrf2/HO-1 signaling pathway. Immunofluorescence staining demonstrated that LXA4 treatment triggered the nuclear aggregation of Nrf2 in infected HCECs at 8 h post-infection in comparison with PBS treatment. A: Magnification, ×600. B: The mRNA and C, D: protein levels of HO-1 were increased in infected groups treated with 10 nM LXA4 compared with PBS control group. All data are presented as mean ± SD and evaluated by an unpaired, two-tailed Student t test (ns: no significance).