To access the data, click or select the words “Appendix 5.” A. Bar graph representation of RPE-specific gene isoforms expressed in all three iPSC-RPE cell lines (see color key), as a function of RPKM. SLOS-derived (“severe”) A2 RPE cells exhibited lower levels of expression of RPE-specific gene isoforms than CWI (“mild,” SLOS-derived) or DYS (control) RPE cells, especially in RPKM values greater than 100. B. Concordance analysis (through Pearson correlation) of RPE-specific gene isoforms showing high concordance between CWI and DYS RPE cells, but low concordance between A2 and DYS RPE cells or between A2 and CWI RPE cells.