To access the data, click or select the words “Appendix 3.” Principal Component Analysis using the RNA-Seq data from the A2 (blue), CWI (green), and DYS (red) iPSC-RPE cells. Each replicate clusters within its sample type. These data demonstrate low replicate-to-replicate variability and distinct differences between the sample types, i.e., disease severity class (“mild” versus. “severe” SLOS) versus. normal control.