Figure 5. SFN treatment reduces microglia and macrophage infiltration in SOD2 knockdown mice. Representative transverse sections of retinas from wild type (WT) and Nrf2 KO mice either untreated, MnSOD KD or MnSOD KD plus SFN treatment. A: Immunostaining for the microglia marker IBA1 (red) shows increased microglia and ramification in the retinas of the MnSOD KD animals and reduction after SFN treatment. B: Immunostaining for the macrophage marker F4/80 (green) shows increased infiltration in the retina following MnSOD KD and reduction after SFN treatment.