Figure 2. SFN improves the photopic b-wave ERG deficit induced by MnSOD knockdown in an Nrf2-dependent manner. Full-field scotopic and photopic electroretinography (ERG) were performed on WT and Nrf2 KO mice. Error bars represent SEM (standard error of the mean). A–C: Graphs show baseline scotopic a-waves, scotopic b-waves, and photopic b-waves, respectively, for each genotype with data from both eyes combined. D–F: Graphs of baseline scotopic a-waves, scotopic b-waves, and photopic b-waves, respectively, for each genotype from the right (OD) and left (OS) eyes. G–I: All mice were injected with AAV1-RzSOD2 in the OD, and 1 month post-AAV administration, ERGs were recorded. J–L: One month post-AAV administration, mice from each genotype were evenly divided into two groups and treated with either vehicle (Veh) or SFN. After 3 months of treatment (i.e., 4 months post-AAV administration), a final set of ERGs were recorded for each animal. Statistical significance (p<0.05) was determined with an unpaired Student t test or one-way ANOVA using GraphPad Prism.