Figure 1. Study schematic. Baseline electroretinography (ERG) and OCT measurements from 6- to 8-month-old WT and Nrf2 KO mice were recorded before any interventions, and the animals were subsequently injected subretinally with AAV1-RzSOD2 to knock down MnSOD enzyme expression in the RPE layer of the right eyes (OD). The contralateral eye (OS) was untreated. One month later, ERG and OCT measurements were taken again, and the mice were administered sulforaphane (50 mg/kg) or vehicle every Monday, Wednesday, and Friday for 3 months. Mice were 10–12 months old at the end of the study. Final ERG and OCT measurements were recorded before postmortem harvesting of the posterior eyes for histopathology and immunohistochemistry.