To access the data, click or select the words “Appendix 1.” Longitudinal analysis of ERG amplitudes in WT and Nrf2 KO mouse eyes comparing measurements taken 1 month and 4 months post AAV1-RzSOD2 injection. The ERG differences between the two time points were not statistically significant in either genotype for the scotopic a-wave (A), the scotopic b-wave (B), or the photopic b-wave (C). All comparisons represent mean + SEM, p>0.05 using t test and one-way ANOVA n≥6 mice per genotype per treatment. (D) Representative photomicrographs taken with a 60× objective of RPE sections labeled with an MnSOD antibody from WT and Nrf2 KO eyes that have not (-Rz) or have (+Rz) been injected with a ribozyme targeting MnSOD expression. Mice were treated with vehicle (Veh) or SFN (SFN). Graph compiled from 3 independent sections quantified for each experimental condition. No statistically significant differences (ns) were detected between MnSOD levels using Student t test. (E) Representative photomicrographs taken with a 20× objective of retinal sections labeled with an MnSOD antibody, as in (D). MnSOD expression in the inner segments of Nrf2 KO mice compared to WT mice trended toward but did not reach statistical significance (ns) using Student t test.