Figure 2. Clinical images of subjects II:1 and III:1. A: Clinical image of Subject II:1, showing retinal manifestations of outer retinal degeneration. The infrared scanning laser ophthalmoscopy (SLO-IR; a, c) and spectral-domain optical coherence tomography (SD-OCT; b, d) images of each eye show a perifoveal ellipsoid zone and outer nuclear layer loss, with preservation of these layers in the foveal center. Focal vitreomacular traction with distortion of the foveal contour can be observed in the right eye, whereas subtle cystic changes can be observed in the inner nuclear layer temporal to the fovea in the left eye. B: Macular image of Subject III:1. The infrared SLO-IR (a, c) and SD-OCT images (b, d) show preservation of the perifoveal ellipsoid zone and outer nuclear layer in the fovea, with perifoveal thinning of these structures in each eye. Calibration bars: 200 µm.