Table 3 of
Chu, Mol Vis 2022; 28:230-244. Table 3 of
Chu, Mol Vis 2022; 28:230-244.
Table 3. Targeting analysis of key metabolites of diabetic macular edema (DME) and the diabetes mellitus (DM) control groups (n=18 for each group) using exact mass quantification.
| Metabolite | Ionization species | Mass (m/z) | Fold change (DME/DM) | p-value |
|---|---|---|---|---|
| Methylselenic acid* | [M+Cl]- | 162.9053 | 1.697 | 0.018 |
| Homovanillic acid*** | [M+H-H2O]+ | 165.0519 | 2.170 | 3.58439E-06 |
| L-Homocysteine* | [M+K]+ | 173.9989 | 0.354 | 0.05 |
| 2-Undecenoic acid*** | [M+H]+ | 185.1565 | 1.601 | 0.000252385 |
| b-Glucose*** | [M+Na]+ | 203.0503 | 1.172 | 1.20122E-05 |
| 5-Hydroxytryptophan*** | [M+H-H2O]+ | 203.0869 | 2.206 | 5.50427E-05 |
| 7,8-Diaminononanoate*** | [M+Na]+ | 211.1454 | 1.969 | 0.000150843 |
| Dehydroascorbic acid** | [M+CH3COO]- | 233.0307 | >1000 | 0.003 |
| Sorbitol-6-phosphate*** | [M+Na]+ | 285.0346 | 0.662 | 6.81668E-05 |
| 13,14-dihydro-15-keto-tetranor PGF1α* | [M+H]+ | 301.2019 | 1.779 | 0.028 |
| Glutathione amide*** | [M+Na]+ | 329.0886 | 0.533 | 0.00035509 |
| 19(R)-hydroxy-PGF1α* | [M-H2O-H]- | 353.2348 | 1.782 | 0.037 |
| Decanoyl-L-carnitine*** | [M+CH3COO]- | 374.2586 | 1.571 | 0.000425371 |
| C16 sphingosine-1-phosphate*** | [M+CH3COO]- | 410.2352 | 1.485 | 8.64966E-05 |
| Se-Adenosylselenohomocysteine*** | [M+H]+ | 433.0747 | 0.650 | 1.61927E-06 |
| Uridine diphosphate (UDP)** | [M+CH3COO]- | 463.0174 | <0.01 | 0.007 |