Figure 3. Pathways analyzed using Metscape. The schematic diagram summarizes different pathways and their interactions found using Metascape. The following six main pathways were found in diabetic macular edema (DME) patients: (A) tyrosine metabolism, (B) pentose phosphate, galactose, glycolysis and gluconeogenesis metabolism, (C) glycine, serine, alanine, threonine, methionine, cysteine, and selenoamino acid metabolism, (D) pyrimidine metabolism and glycosphingolipid biosynthesis, (E) glycosphinolipid metabolism, and (F) ascorbic acid metabolism pathways. A hexagon indicates the identified metabolites with upregulation (↑) and downregulation (↓). The thicker arrow indicates higher activation of the pathway.