Figure 1. Score plots of aqueous humor samples from diabetic macular edema (DME; black square) and normal diabetic control patients (DM; red square) as analyzed using orthogonal partial least square discriminant analysis (OPLS-DA). Samples were analyzed using (A) positive electrospray ionization (ESI) and separated by an ultra-performance liquid chromatography (UPLC) nano-C18 column and (B) negative ESI and separated by an HPLC hydrophilic cyano (HILIC CN) micro-column (bottom).