To access the data, click or select the words “Appendix 5.” Four pathway networks were identified. The metabolites participates the pathways are (a) Tyrosine metabolism pathway, (b) pentose, galactose, glycolysis and gluconeogenesis metabolism pathway, (c) Glycine, serine, alanine, threonine, methionine, cysteine, selenoamino acid metabolism pathway, and (d) pyrimidine and glycosphingolipid biosynthesis pathway. – Big red hexagon with green outline indicates the identified input metabolites with significant level increased. Big red hexagon– small red hexagon with green outline indicates the identified input metabolites with significant level reduced.green rectangle – enzyme involved the reaction; diamond– associated reaction in the pathway; circle – gene involved in the reaction; – pink hexagon is associated metabolites deduced by Metacape during pathway exploration. The orange color text labeled in the reaction indicates a single direction reaction. The purple color text labeled in the reaction indicates a two ways reaction. Single arrow indicates single direction reaction. Double arrows at both ends indicate bidirectional reaction.