To access the data, click or select the words “Appendix 3.” It shows some significant impact pathways. It shows the (a) pathways, ascorbate and aldarate, starch and sucrose, tyrosine, sulfur, selenoamino acid, and biotin, are significantly affected in diabetic macular edema (DME) patients; and metabolites present in different topological position in (b) biotin, (c) selenoamino acid, (d) ascorbate and aldarate, (e) tyrosine, and (f) starch and sucrose pathway. Red color boxes indicate the significantly identified metabolites while the blue boxes indicate the relevant metabolites in the pathway proposed by the software.