Figure 7. Baseline outflow facility and Mmp gene expression were not altered in C57BL/6 mouse eyes. A: Outflow facility in protein-treated C57BL/6 mouse eyes. Outflow facility (mean ± SD µl/min/mmHg) was unchanged following treatment in non-steroid-treated eyes exposed to tPA (n = 11) and NE-tPA (n = 11) compared to those treated with BSA (n = 19; p>0.05, ANOVA). The outflow facility of naïve (not treated with protein) C57BL/6 animals is included for comparison. The outflow facility in these eyes was similar to the outflow facility in tPA-, NE-tPA- ,or BSA-treated C57BL/6 eyes. Group means of gene expression changes in Mmp-2 (B), Mmp-9 (C), Mmp-13 (D), and Plat (E) were not significantly different in BSA eyes (n = 12), tPA eyes (n = 8), or NE-tPA eyes (n = 8; p>0.05, ANOVA).