Figure 8. Gene expression in the Western diet (WD) fed and Standard diet (SD) fed Ossabaw pig corneas. A represents collagen-related genes- collagen 3 (COL 3), collagen 4 (COL 4), metalloproteases 1 (MMP1), metalloproteases 9 (MMP9), and tissue inhibitor of metalloprotease 1 (TIMP1). B represents fibrosis-related genes alpha-smooth muscle action (ɑSMA), transformation growth factor beta 1 (TGFβ1), and fibronectin (FN). The WD-fed Ossabaw mini pigs corneas had significant alterations in COL4, MMP9, ɑSMA, TGFβ1, and FN. compared to the SD-fed pigs (P, *<0.05, **<0.01, ***<0.001, ****<0.0001).