Figure 2. Anti-TNF-α and anti-VEGF therapy reduced the proangiogenic effects of M1 macrophages in an in vivo rat model of laser-induced CNV. Fluorescence images and summary of the choroidal neovascularization (CNV) area (in square millimeters) measured following the indicated treatments in the laser-induced CNV (LI-CNV) model (see Materials and Methods for details). The laser injury sites are indicated with arrows, and the optic disc is indicated with a “+.” n = 8 eyes in four rats/group. *p<0.05 versus PBS; #p<0.05 versus eyes injected with M1 macrophages alone.