Figure 6. Chemerin promotes the migration of rat primary retinal microvascular endothelial cells (RRMECs) via activation of ChemR23. A,B: The effects of different glucose concentrations (5.5, 20, and 30 mM) on RRMEC migration. C,D: The effect of the chemerin/ChemR23 pathway on RRMEC migration under low-glucose condition (5.5 mM). E,F: The effect of the chemerin/ChemR23 pathway on RRMEC migration under high-glucose condition (30 mM). The representative images were photographed and quantitative analysis of the scraping area was performed at 0 and 24 h after scraping. The experiment was conducted in triplicate. **p<0.01, ***p<0.001. Abbreviations: NC, RRMECs transfected with empty vector; shChemR23, RRMECs transfected with shRNA targeting ChemR23.