Table 2 of
Sharma, Mol Vis 2021; 27:480-493. Table 2 of
Sharma, Mol Vis 2021; 27:480-493.
Table 2. A summary of the different approaches directed against myocilin for treating myocilin associated glaucoma.
| Method | Mode of Action | References |
|---|---|---|
| Treatment with chemical chaperones | Relieve ER stress by promoting folding of mutant myocilin | Yam et al. 2007 [146], Burns et al. 2016 [145], Zode et al. 2011 [147], Zode et al. 2012 [148] |
| CRISPR-Cas9 mediated gene editing | Cutting the expression of mutant myocilin | Jain et al. 2017 [76] |
| Inhibiting myocilin aggregation | Small molecules promoting stability and preventing myocilin aggregation | Orwig et al.. 2014 [149] |
| Inhibition of grp94-myocilin interaction | Promoting clearance of mutant myocilin via autophagy | Stothert et al. 2014 [114], Crowley et al. 2016 [115], Stothert et al. 2017 [117], Huard et al. 2018 [116], |